http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CA-1075691-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_5c24684033fba97d1ad845ce453a57e3 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D473-06 |
| filingDate | 1977-12-07-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 1980-04-15-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_b040ca8d26954911a63bb6aa4725654e http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_9574eb745223f588382bf7c89fa8238a http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_7fd330d5cd458152d2de6d39dc1c60ec |
| publicationDate | 1980-04-15-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CA-1075691-A |
| titleOfInvention | Xanthine derivatives |
| abstract | ABSTRACT This invention relates to a process for the preparation of the compounds of general formula (I) wherein R1 is a straight-chain 5-oxohexyl group, R2 is alkyl having at most 2 carbon atoms and R3 is a straight-chain or branched alkyl group containing from 2 to 4 carbon atoms, and physiologically acceptable acid addition salts thereof, which comprises a) reacting an alkali metal salt of a 3-methyl- or 3-ethyl-7-alkyl-xanthine with a substance selected from the group consisting of a 1) a compound of formula (III) wherein A is an alkylene group containing 4 carbon atoms and Hal is a halogen atom; b 1) an acetal, c 1) ketal and d 1) thioketal therefrom and subsequently hydrolysing the product, or b) reacting an alkali metal salt of 1-(5-oxohexyl)-3-methyl- or 3-ethyl-xanthine with an alkylating compound selected from the group consisting of alkyl halides and a dialkyl sulphate wherein the alkyl group or groups contain 2 to 4 carbon atoms in the presence of a solvent, or c) reacting a compound of formula (IV) wherein X is an alkylene group containing 3 carbon atoms and Hal is a halogen atom with an alkali metal salt of an acetoacetate and subsequently subjecting the reaction product to ketone splitting to obtain a product of general formula (I) as defined above, or d) oxidation of a compound of formula (V) wherein R2 and R3 have the meaning as defined above and Y is a 5-hydroxyhexyl group; and wherei.n the product obtained is isolated per se or reacted with an acid to form a physiologically compatible acid addition salt thereof. It also relates to the products of this process which are useful in the treatment of diseases involving deficiencies in the blood vascular system. |
| priorityDate | 1977-12-07-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 145.