http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CA-1057284-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_8a0e90292f2ba83d7878baca3838b8a2 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D205-095 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D501-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D501-18 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D205-095 |
| filingDate | 1975-06-10-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 1979-06-26-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_4f0dfc4835f36dc99706936f777d1b27 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_a4a22746f15979a94f30c72f223e531f http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_c37b5286121fb4a4f5b7b6e40eeeb3fe http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_d2c2359b5528210c9d782f81189f2083 |
| publicationDate | 1979-06-26-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CA-1057284-A |
| titleOfInvention | Process for preparing cephalosporins and intermediates |
| abstract | ABSTRACT OF THE DISCLOSURE A process is disclosed for preparing derivatives of 7-amino-cephalosporanic acid and 7-amino-desacetoxycephalosporanic acid of structure: (V) were R1 is selected from the class consisting of hydroxyl, alkoxy with 1 to 4 carbon atoms, trichloroethoxy, benzyloxy, p-methoxy-benzyloxy, p-nitrobenzyloxy, benzhydryloxy, triphenylmethoxy, phenacyloxy, and p-halophenacyloxy; Z is selected from the class consisting of hydrogen, hydroxyl, -O-alkyl, -O-CO-alkyl, -Br, -I. -N3, -NH2, -O-CO-CH3, O-CO-NH2, and an S-mononuclear hetero-cyclic ring, starting from a 3-acylamino-2.beta.-thiohydrazoazetidinone structure: (II') were R is selected from the class consisting of hydrogen, alkyl having from 1 to 4 carbon atoms, cyano-methyl, thienyl-methyl, furyl-methyl, naphthyl-methyl, phenyl-methyl, phenoxy-methyl, phenyl-isopropyl, phenoxy-isopropyl, pyridyl-4-thiomethyl, and tetrazolyl-1-methyl; R2 and R3 are equal or different and represent a lower alkyl, a mononuclear aryl ring, CN, a mononuclear hetero-cyclic ring or the radicals -COR4, -COOR4, -?- (OR4)2, -CONHR4, Abstract continued ... or R2 and R3 together may represent the residues: where T represents , ; and R4 is a lower alkyl, a mononuclear aryl ring or a mononuclear heterocyclic ring, wherein the compound (II') is reacted with a phosphorous halide such as phosphorus pentachloride or phosphorus oxychloride in the presence of a tertiary amine such as pyridine, the corres-ponding imino chloride is reacted with a lower aliphatic alcohol, the iminoether so formed is hydrolyzed with water in an acid medium, and the resultant 3-amino-2 .beta.-thiohydrazoazetidinone of structure: (IV') in which R1, R2, R3 and Z have the meanings given heretofore, is reacted in a suitable solvent and at a temperature between -100° and +120°C with a compound selected from the class con-sisting of inorganic basic or weakly acid oxides and inorganic and organic bases, to finally give the desired compound (V) which is isolated and purified in known manner; 2.beta.-thiohydrazoazeti-dinones are also disclosed as intermediates. |
| priorityDate | 1974-06-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 84.