http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CA-1056813-A
Outgoing Links
Predicate | Object |
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assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_97a285d8ecd0184a7e5d89a1e4e07997 |
classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D501-20 |
filingDate | 1978-09-13-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
grantDate | 1979-06-19-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_f77bff118cb6dcf1283edd09327363e7 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_71c068402b92610c2db54e80899c1a2f |
publicationDate | 1979-06-19-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
publicationNumber | CA-1056813-A |
titleOfInvention | .alpha.-AMINO- (P-ACYLOXYPHENYL) ACETAMIDOCEPHALOSPORANIC ACID DERIVATIVES |
abstract | ABSTRACT OF THE DISCLOSURE This specification discloses certain novel .alpha.-amino- or .alpha.-formyl-.alpha.-(p-acyloxyphenyl)acetamidocephalosporanic acids which are useful as antibacterial agents, and methods of making them. The novel cephalosporin derivatives of this invention comprise the D-(-) compounds of the formula I wherein Y is hydrogen or S-Het, in which Het represents a 5 or 6 membered heterocyclic ring containing 1 to 4 atoms selected from N, O or S, said heterocyclic ring being optionally sub-stituted by C1-C4 alkyl which may be optionally substituted by a carboxylic acid group or hydroxy, or alkoxyalkyl of up to 4 carbon atoms; R is hydrogen, C1-C10 alkyl optionally sub-stituted by carboxylic acid, or phenyl optionally substituted by C1-C4 alkyl, halogen, nitro, amino or trifluoromethyl; R' is hydrogen, hydroxy, C1-C4 alkyl, C1-C4 alkoxy or halogen, and pharmaceutically acceptable salts thereof, when substantially free of the L-(+) isomer, and the D-(-) compounds of the formula I(a) (Ia) wnerein Y is S-Het, in which Het is 1,2,3-triazol-5-yl, 1-N-methyl-tetrazol-5-yl or 2-methyl-1,3,4-thiadiazol-5-yl; R is hydrogen, C1-C10 alkyl optionally substituted by carboxylic acid, or phenyl optionally substituted by C1-C4 alkyl, halo-gen, nitro, amino or trifluoromethyl; R' is hydrogen, hydroxy, C1-C4 alkyl, C1-C4 alkoxy or halogen, and pharmaceutically acceptable salts thereof, when substantially free of the L-(+) isomer. |
priorityDate | 1974-06-05-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 85.