http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CA-1056376-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_3b9f373878f16dc291ff597162e9b344 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C405-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C405-0016 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C67-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D257-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D309-12 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D257-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C405-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C401-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-5575 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-21 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-19 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D307-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-16 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D309-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C67-00 |
| filingDate | 1975-09-05-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 1979-06-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_ba73e614901c1b2247d35ad7993adcd3 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_4733d9555e85dce9e20463ab29080e13 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_93689f0da116e21bfe0c5feee56c986f |
| publicationDate | 1979-06-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CA-1056376-A |
| titleOfInvention | PGF .beta.-PROSTAGLANDINS AND PROCESS FOR THEIR PREPARATION |
| abstract | A B S T R A C T New therapeutically useful PGF.beta. prostaglandins having the formula (I) (I) wherein R is a tetrazolyl or a -CH2-OH group or a -COOR"' group, wherein R " ' is an amino group or an-ORIV radical, wherein RIV is hydrogen, C1-C12 alkyl, trihaloalkyl or a pharmaceutically acceptable cation; R1 may be hydrogen or a CORb acyl, wherein Rb may be hydrogen or C1-C10 alkyl, a ? -(CH2)n1 -radical,wherein n1 may be zero or an integer number of 1 to 5 and ? is a phenyl radical which may be unsubstituted or substituted by one or more substituents selected from the group consisting of halogen, alkoxy, trifluoromethyl, phenyl and cycoalkyl-alkyl, or Rb may be the following radical: wherein m is an integer number of 1 to 4, X is -CH2- or an oxygen or a sulphur atom and n1 is s above defined; one of R2 and R3 is hydroxy and the other is hydrogen or C1-C6 alkyl R4 and R5 are independently hydrogen or C1-C6 alkyl; n is zero or n integer of 1 to S; R6 is hydrogen or a group, wherein X and m are as above defined; A may be -CH2-CH2- or cis-CH=CH-, and wherein - when at the same time R is -COR" ', wherein R " ' is an ORIV radical, n is 3 or 4, A is cis-CH=CH-, R1 and R6 are hydrogen and one of R4 and R5 is hydrogen - the other is a 165- or 16R- C1-C6 alkyl. Also described is an im-proved process for the preparation of PGF.beta. prostaglandins and their 9-acyloxy derivatives comprising the selective esterification with s carboxylic acid of the 9.alpha.-hydroxy group of a PGF.beta. prostaglandin, in prusence of a compound of compound of formula MV Y3, wherein MV is a metalloid of the V group and Y is an alkyl, a dialkylamino or an aryl group, and of a hydrogen-acceptor agent, so as to obtain directly a PGF.beta.-9-acyloxy derivative which may be converted into the desired PGF.beta. prostaglandin by conventional methods. |
| priorityDate | 1974-09-06-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 118.