http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CA-1051442-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_1374dd16777534b65ad4422333245af8 |
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/Y02P20-55 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A23K20-174 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07J71-001 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07J9-00 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A23K1-16 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07J9-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07J71-00 |
| filingDate | 1975-06-17-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 1979-03-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_981d2e5336212cf31df2d75ea1185cfa http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_d0d989f708487fdae6afa51823cccdda http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e3354d142958dbe705a3ddb0900316f6 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_d25df5da84cb98394ad0bc2cc741b3f9 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_624bb673356d0d9bbc699c0b447c2346 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_05ab08dbd527d56843615e62f5c0a04d |
| publicationDate | 1979-03-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CA-1051442-A |
| titleOfInvention | 1.alpha.,24-DIHYDROXYCHOLECALCIFEROLS, NOVEL PRECURSORS THEREOF, AND PROCESSES FOR PREPARING THEM |
| abstract | ABSTRACT Novel 1.alpha., 24-dihydroxycholecalciferol and derivatives thereof which are useful with reduced side-effects for the treat-ment of abnormal metabolism of calcium and phosphorus caused by liver failure, renal failure, gastrointestinal tract failure and parathyroid failure, and related bone diseases. Preparation of the novel 1.alpha. , 24-dihydroxycholecalciferol and their derivatives starts from 1.alpha. , 24-dihydroxycholesterol prepared by reacting 1.alpha. , 2.alpha. -epoxy-24-keto-cholesta-4,6-dien-3-one with an alkali metal and a proton donor in the presence of liquid ammonia or a liquid amine. Reaction of the 1.alpha. , 24-dihydroxycholesterol with an allylic bromina-ting agent, followed by contacting with a dehydrobrominating agent, affords 1.alpha. , 3.beta. , 24-trihydroxycholesta-5,7-diene derivative, which can then be converted to 1.alpha., 24-dihydroxycholocalciferol by ultra-violet irradiation in an organic solvent, followed by isomerization. Processes are also provided for separating 1.alpha., 24-dihydroxychole-sterol into an (S)-epimer and an (R)-epimer, and also for separating at least one of 1.alpha., 3.beta., 24(S)- and 1.alpha., 3.beta., 24(R)-trihydroxycholesta-5,7-dienes fromtrihydroxycholesta-4,6-diene. . |
| priorityDate | 1974-06-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 187.