| abstract |
ABSTRACT Method of preparing new derivatives of D,L - tyrosine of the formula: comprising di-acylating D,L-tyrosine, amidating the carboxyl group of the diacyl derivative to obtain an amidoester, hydrolyzing the amidoester thereby obtaining its corresponding diamido-derivative, and etherifying the latter. In the above formula R1 is a linear or branched chain alkyl radical having 1 to 6 carbons and terminating in a tertiary amino group; R2 is a phenyl group which may be substituted by chlorine, bromine nitro, methoxy or methyl; and R3 is a secondary or tertiary amino group. The new derivatives of D,L-tyrosine have antispastic activity in animals. |