http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CA-1048016-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_232361c9031a709144573276863c462b |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D501-26 |
| filingDate | 1977-12-23-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 1979-02-06-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_01f831d58ec563b6bdd53bec80a48aa6 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_1ccf0fb971dc48c968d8f832acfe5593 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_113db67a041d2959b4d82630d7fd57cf |
| publicationDate | 1979-02-06-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CA-1048016-A |
| titleOfInvention | Antibiotics |
| abstract | ABSTRACT OF THE DISCLOSURE Cephalosporin antibiotics in which the 7.beta.-acylamido group has the structure where R1 is a furyl, thienyl or phenyl group and R2 is a C1-C4 alkyl, C3 -C7 cycloalkyl or phenylgroup except that R2 may not represent a methyl group when R1 represents a furyl group, and in which the 3-position substituent is a carbamoyloxymethyl group possess a particularly valuable combination of properties, exhibiting high anti-bacterial activity against a broad range of gram positive and gram negative organisms, particularly high stability to .beta.-lactamases produced by various organisms, and stability in vivo. Such compounds include the non-toxic salts, biologically acceptable esters, 1-oxides and solvates of the parent 4-carboxylic acids. The compounds are syn isomers or exist as mixtures of syn and anti isomers containing at least 90% of the syn isomer. The above compounds may be prepared by (a) acylation of the corresponding 7-amino compound or (b) carbamoylation of the corresponding 3-hydroxymethyl compound. |
| priorityDate | 1973-08-21-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 146.