http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CA-1047493-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_69c91bbf0395db010b4806f50d808c4e |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P3-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-20 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D243-26 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P39-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D243-24 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P25-20 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D243-26 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D243-18 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P39-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-5513 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-55 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-551 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D243-24 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D243-16 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P3-00 |
| filingDate | 1975-06-24-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 1979-01-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_6cb3729b65365bcb045a0eea5415c2ad http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e7d618e4421f20e4f3a3d9c400f2390c http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_9e6cce3e4af81a1e51af4e530e70409b http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_c028ee521b90b04c109b0f3f202ea0d4 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_604b6c87ca20151ccbf4a88a27f93fce http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_2f455f790d40a7a793b19a5ad8abbdf1 |
| publicationDate | 1979-01-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CA-1047493-A |
| titleOfInvention | Benzodiazepine derivatives and a process for the preparation thereof |
| abstract | ABSTRACT OF THE DISCLOSURE New benzodiazepine derivatives of the general formula (I), (I) wherein R1 stands for halogen, trifluoromethyl, nitro or amino, R2 stands for hydrogen or alkyl, and R3 stands for nitroso, amino, optionally substitued alkylidene-amino, optionally substituted aralkylideneamino or optionally substituted acylamido, are prepared as follows: a 1,3,4,5-tetrahydro-2H-1,4-benzo-diazepine-2-one derivative of the general formula (II), (II) wherein R1 and R2 each have the same meanings as define above, is subjected to direct nitrosation, and, if desired, the thus-obtained N4-niroso compound of the general formula (III), (III) wherein R1 and R2 each have the same meanings as defined above, is reduced, and, if desired, a) the thus-obtained N4-amino compound of the general formula (IV), (IV) wherein R1 and R2 each have the same meanings as defined above, is reacted with an aldehyde of the general formula (V), R4-CHO (V) wherein R4 stands for an optionally substituted alkyl, aryl or aralkyl group, or b) the N4-amino compound of the general formula (IV), obtained as described above, is reacted with a compound of the general formula (VI), R3-CO-Y (VI) wherein Y stands for halogen or hydroxy and R5 stands for an optionally substituted aliphatic or aromatic hydrocarbyl group, and, if is desired, any compound of the general forming (I), wherein R2 stands for hydrogen and the other substituents are as defined above, is alkylated. The new compounds according to the invention possess remarkable enzyme-inducing effects and exert only moderate central nervous activities. |
| priorityDate | 1974-06-25-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 125.