| abstract |
HETEROCYCLIC N-GLYCINYL-N-ACYLIDRAZONIC COMPOUNDS, SYNTHESIS PROCESS, PHARMACEUTICAL COMPOSITIONS AND TREATMENT AND NTO METHODS New heterocyclic derivatives having the inhibitory anti-inflammatory analgesic N-glycinyl-N-acylhydrazone subunit are described. in vitro and in vivo, on the production of proinflammatory cytokine TNF-a and are therefore useful in the treatment of acute and chronic pain and inflammation, including: relief of hyperalgesia associated with acute and chronic inflammation in mammals, preferably humans; Also disclosed are pharmaceutical compositions containing said compounds and processes for their preparation. |