| abstract |
ALDIMINE DERIVATIVE COMPOUNDS, PHARMACEUTICAL COMPOSITIONS AND USE. The present invention comprises aldimine-derived compounds as well as pharmaceutical compositions containing such compounds and pharmaceutically acceptable excipients, as well as their use in the treatment of fungal infections of medical and / or veterinary importance. The aldimines and derivatives thereof have shown equal or better antifungal action. than commercially available medicines such as fluconazole. Because they are new drugs, the resistance of pathogens to them is greatly reduced. The synthesis of aldimines is carried out through a one-step process in which the reaction develops within two minutes and yields between 70-80%, which enables its large-scale production, as it is a fast and efficient process. compared to other available drugs. |