| abstract |
PROCEDURE FOR OBTAINING NEW NAPHTHALENE DERIVATIVES FOR IN VIVO DIAGNOSIS OF ALZHEIMER'S DISEASE. The present invention relates to a branch of chemistry, particularly to the field of organic synthesis of compounds belonging to the category of bicyclic or naphthalene aromatics, used in the detection of amyloid plaques. These new naphthalene derivatives belong to the general formula (I), (II). Where R represents mutually independent groups. In I: R1 : -alkylenyl-C(O)NH-alkylenyl-R3, -alkylenyl-C(O)O-R4; R3: -COOH, -OH, -SH, -NH2, -alkyl-NH, -alkyl-N-dithiocarbamate of alkaline earth metal salts. R4: succinimidyl group; R2: -H, -alkyl. In II: R1 : -alkyl, -alkylenyl-halide, -alkylenyl-hydroxy, -alkylenyl-O-arylsulfonate, alkylenyl-O-alkylsulfonate; R2: -halide, -alkylenyl-O-arylsulfonate, -alkylenyl-O-alkylsulfonate, -alkylenyl-halide, -CH(O), -HC=C(CN)2, -HC=CHNO2, alkylenyl-NH2, -alkylenyl -NH-alkyl, -alkylenyl-alkyl-N-dithiocarbamate of alkali salts. The terms "alkyl" and "alkylenyl" refer to straight or branched aliphatic chains, preferably from 1 to 4 carbon atoms and the term halide refers to fluorine, bromine or iodine. low, and therefore they cross the blood-brain barrier and attach to the amyloid plaques. |