| abstract |
compound, pharmaceutical composition and medicament having destructive muscle contraction activity and relaxing muscle activity of the urethal sphincters disclosed herein is a compound represented by the general formula (i) (where all symbols are as defined in the description), a salt or solvate of the compound , a prodrug of the compound, a mixture with a diastereoisomer thereof in an arbitrary proportion, or a cyclodextrin clathrate thereof, which has bladder detrusor muscle contraction activity and urethral sphincter relaxation activity, and, It, for example, may improve bladder contraction dysfunction and / or dysfunction in urethral relaxation, for example, for the underactive bladder. furthermore, the compound of the present invention has low risk of side effects on the urinary, circulatory and digestive system, and exhibits excellent pharmacokinetics as well as oral absorption, etc. therefore, the compound of the present invention is useful as a superior agent for prevention, treatment and / or enhancement of the hypoactive bladder. |