| abstract |
1,2,4-triazolo [4,3-a] pyridine derivatives and their use as positive allosteric modular mglur2 receptors. the present invention relates to new triazole [4,3-a] pyridine derivatives of formula (i) wherein all radicals are as defined in the claims. the compounds according to the invention are positive allosteric modulators of the metabotropic glutamate receptor subtype 2 ("mglur2"), which are useful for the treatment or prevention of neurological and psychiatric disorders associated with glutamate dysfunction and diseases in which the sub- mglur2 type of metabotropic receptors is involved. the invention is also directed to pharmaceutical compositions comprising such compounds, to processes for preparing such compounds and compositions, and to the use of such compounds for the prevention or treatment of neurological and psychiatric disorders and diseases in which mglur2 is involved. |