| titleOfInvention |
binding molecule, functional variant of the binding molecule, immunoconjugate, pharmaceutical composition, use of the binding molecule, nucleic acid molecule. vector, host, and method for producing a binding molecule. |
| abstract |
binding molecule, functional variant of the binding molecule, immunoconjugate, pharmaceutical composition, use of the binding molecule, nucleic acid molecule, vector, host, and method for producing a binding molecule the present invention relates to binding molecules, such human monoclonal antibodies, which bind to the influenza virus which comprises ha of the h3 subtype, such as h3n2 and has a broad neutralizing activity against such influenza viruses. the disclosure provides nucleic acid molecules that encode the antibodies, their sequences and compositions that comprise the antibodies and methods of identifying or producing the antibodies. antibodies can be used in the diagnosis, prophylaxis and / or treatment of an infection by the influenza virus h3n2. in a preferred embodiment, antibodies provide cross-subtype protection, such that infections with influenza subtypes based on h3, h7, and / or hio can be prevented and / or treated. |