http://rdf.ncbi.nlm.nih.gov/pubchem/patent/BR-PI1010481-A2
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_89ac64d62baaa791ac712c93832985fd http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_113bb27af6baee1774da28ada026244b |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-63 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-861 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-86 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K48-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-12 |
| filingDate | 2010-04-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_30f82d5d1353d195bef3dfe5a52df29a |
| publicationDate | 2012-08-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | BR-PI1010481-A2 |
| titleOfInvention | bicistronic vector, process of obtaining bicistronic vector, use of bicistronic vector for preparation of drug for gene therapy; pharmaceutical composition and use of bicistronic vector in gene therapy |
| abstract | Bicistronic vector, process of obtaining the bicistronic vector, use of the bicistronic vector to prepare medicine for gene therapy; pharmaceutical composition and use of the bicistronic vector in gene therapy. The present invention consists of a bicistronic vector containing the combination of at least one promoter responsive to p53, at least one gene of the Interferon pathway (IFN) and / or at least one complementary DNA (cDNA) for a gene of the p53 / Arf pathway. . The combination of these factors leads to a more effective vector with the ability to self-regulate the expression of genes for p53, IFNI <225> and Arf (human, p14ArI; murine, pl9Arf). The present invention also comprises the use of the bicistronic vector in the production of pharmaceutical compositions and / or for the preparation of medicines and its use in gene therapies, more preferably in cancer gene therapy, since the bicistronic vector has activity in inhibiting tumor proliferation, cell death and anti-tumor immune memory of primary or metastatic cancers. |
| priorityDate | 2010-04-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 454.