| abstract |
gene encoding mutant human glucokinase, mutant human glucokinase, recombinant vector, host, pharmaceutical composition, use of a gene, a mutant human glucokinase, a recombinant vector, a host and a pharmaceutical composition the gene encoding human glucokinase mutant is provided. the gene has the nucleotide sequence chosen from the nucleotide sequence listed as seq id no: 2 and the nucleotide sequence in which the orf region encodes the same amino acid sequence as that encoded by the orf region (position 487 to 1884) of the seq id no: 2 and the remaining region is the same as the non-orf region of seq id no: 2. the gene-encoded mutant human glucokinase, the recombinant vectors that carry the gene, the hosts that comprise the vectors, compositions pharmaceuticals thereof, their use, and methods of treating and preventing disease by use thereof are provided. the gene-encoded mutant human glucokinase has higher activity than wild-type human glucokinase, and thus provides a new way of controlling blood glucose or preventing and treating carbohydrate metabolism disorders, especially preventing and treating diabetes. |