| abstract |
process for the selection of an anti-cxcr4 antibody, isolated antibody, isolated nucleic acid, vector, bacterial or yeast host cell, method for antibody production, composition, use of an antibody and murine hybridoma. the present invention relates to a new isolated antibody, or derivative compounds or functional fragments thereof, capable of binding to cxcr4, but also to induce conformational changes in cxcr4 homodimers and / or heterodimers. more particularly, the present invention relates to antibodies 414h5 and 515h7, specific for cxcr4 proteins, as well as their use for the treatment of cancer. pharmaceutical compositions comprising these antibodies and a process for selecting these antibodies are also covered. |