| abstract |
NEW HETEROCYCLESnNew heterocyclic compounds of the general formula (I), their derivatives, analogs, tautomeric forms, stereoisomers, polymorphs, hydrates, solvates, pharmaceutically acceptable salts, pharmaceutical compositions, metabolites and prodrugs thereof are described. These compounds are useful in the treatment of immune diseases, inflammation, pain disorder, rheumatoid arthritis, osteoporosis, multiple myeloma, uveitis, acute and chronic myelogenous leukemia, atherosclerosis, cancer, cachexia, induced ischemic cell damage, pancreatic beta cell destruction, osteoarthritis , rheumatoid spondylitis, gouty arthritis, inflammatory bowel disease, ARDS, psoriasis, Crohn's disease, allergic rhinitis, ulcerative colitis, anaphylaxis, contact dermatitis, muscle degeneration, asthma, COPD, bone resorption diseases, multiple sclerosis, sepsis, septic shock , toxic shock syndrome and fever. More particularly, these compounds are useful as PDE4 inhibitors and are useful for treating PDE4-mediated diseases. |