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filingDate 2009-04-03-04:00^^<http://www.w3.org/2001/XMLSchema#date>
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publicationDate 2020-08-04-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber BR-PI0910898-A2
titleOfInvention ex-vivo multi-dimensional system for the separation and isolation of cells, vesicles, nanoparticles and biomarkers
abstract ex-vivo multidimensional system for the separation and isolation of cells, vesicles, nanoparticles and biomarkers. the present invention relates to devices and techniques that involve a combination of multidimensional electrokinetic, dielectrophoretic, electrophoretic and fluid forces and effects for the separation of cells, nanovesicles, nanoparticles and biomarkers (dna, rna, antibodies, proteins) in biological samples of potency high conductance (ionic) and buffers. in revealed modalities, a combination of continuous and / or pulsed dielectrophoretic forces (dep), direct-field and / or pulsed direct current, microelectrophoresis and controlled fluids are used with electrode series. in particular, the use of dielectrophoretic devices divided into chambers and some devices of relatively larger series of electrodes suitably scaled that combines fluid, electrophoretic and dielectrophoretic forces enables both larger and / or clinically relevant volumes of blood, serum, plasma or other samples be analyzed more directly, quickly and efficiently. the invention makes it possible to create devices and sample diagnostic systems for "unlimited" responses. the devices and techniques described can also perform assisted self-assembly of molecules, polymers, nanocomponents and mesoscale entities in three-dimensional structures of a higher order.
priorityDate 2008-04-03-04:00^^<http://www.w3.org/2001/XMLSchema#date>
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