abstract |
P2X7R ANTAGONISTS AND THEIR USE. The present application is directed to novel P2X7R antagonists which are indole-3-carboxamide or azaindole-3-carboxamide compounds, pharmaceutical compositions comprising them and their use for the prophylactic or therapeutic treatment of diseases mediated by P2X7R activity. Formula (I) - a, b, c, d, x are, at each occurrence, independently selected from carbon, or nitrogen. |