abstract |
compound represented by formula (1), pharmaceutical composition; pai-1 inhibitor and medicament for the prevention and / or therapeutic treatment of disease caused by the manifestation of pai-1 or the increased action of pai-1 compound represented by the following formula (i) having a parent-1 inhibiting action where r1 represents a cs-10 aryl group which may be substituted or the like; t representing a single bond or the like; m being o or 1 when m is g represents -n-c (= o) -c0 2h or similar, when m is 1 g will represent an oxygen atom or similar; r2 represents a substituted aryl group c6 • 10 or the like; and represents formula (11) wherein one of r31, r32, r33 and r34 represent r1-t-, each of the other three independently represents a hydrogen atom or the like, and r35 being formula -x-y ', a hydrogen atom or the like; x represents -ch 2 - or the like, y 'represents a carboxyl group or the like; m represents a single bond or the like. |