| abstract |
Serine Protease Inhibitor Pseudopeptide Compounds, Serino Protease Inhibitor Compositions and Pharmaceutical Compositions Containing Such Compounds Abstract The present invention relates to serine protease inhibitor pseudopeptide compounds that have a rigid core derived from isomanide D-mannitol, capable of conferring rigidity to the inhibitor, and which due to its chemical nature can also act on polymerases, such as DNA or RNA polymerases, inhibiting them. These compounds that inhibit serine proteases and polymerases are the basis of compositions that inhibit serine protease, as well as pharmaceutical compositions for the development of potential antiviral drugs, against viruses of the Flaviviridae family, being mainly related to the Hepatitis C virus (HCV) and the virus of Dengue. |