| abstract |
antimesothelin antibodies and their uses. the present invention relates to recombinant antigen regions and antibodies and functional fragments containing such antigen binding regions that are specific for the 40kda mesothelin polypeptide attached to the membrane that is overexpressed in various tumors, such as pancreatic and ovarian tumors, mesothelioma and lung cancer cells. these antibodies, therefore, can be used to treat these and other diseases and conditions. the antibodies of the invention can also be used in the field of diagnosis, as well as for further investigation of the function of mesothelin in the progression of diseases associated with cancer. the invention also provides nucleic acid sequences encoding the aforementioned antibodies, vectors containing them, pharmaceutical compositions and kits with instructions for use. |