http://rdf.ncbi.nlm.nih.gov/pubchem/patent/BR-PI0813990-A2
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_f5bcd4986b341cf8b84e060483471051 |
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C2603-44 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C231-12 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C237-26 |
| filingDate | 2008-07-07-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_baf1967ff202bdb5d6bcbbea325acec8 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_a11a1b8a14b68685bf41602794bde20e http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_d19defb88292415803dff4d921816bac |
| publicationDate | 2011-09-13-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | BR-PI0813990-A2 |
| titleOfInvention | Methods for Synthesizing Substituted Minocycline Compounds |
| abstract | METHODS FOR SYNTHESIZING COMPOUNDS AND REPLACED MINOCYCLINE. Methods for synthesizing a carboxaldehyde-substituted minocycline compound comprising reacting a reactive minocycline intermediate under appropriate conditions with carbon monoxide, a palladium catalyst, a phosphine binder, a silane and a base, such that said tetracycline compound is replaced by carboxaldehyde is synthesized. The palladium catalyst is chosen from PdCI ~ 2 ~ (tBu ~ 2 ~ FP dichlorobis) ~ 2 ~ (di-tert-butylphenylphosphine palladium (II)] or PdCI ~ 2 ~ (DPEPhos) [palladium (II) chloride and bis (diphenylphosphinophenyl) ether]. The tetracycline reactive intermediate contains selected portions of halogens and triflates Methods of synthesizing a substituted tetracycline compound comprising reacting the carboxaldehyde-substituted tetracycline compound under palladium-catalyzed coupling conditions, hydrogenolysis conditions or conditions reductive amination. |
| priorityDate | 2007-07-06-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 199.