| abstract |
variant of phenylalanine ammonia-lyase of anabaena variabilis, pharmaceutical composition, and uses of a variant of phenylalanine ammonia-lyase of anabaena variabilis. the present invention is directed to phenylalanine ammonia lyase (pal), produced by prokaryotes, in which this prokaryotic pal, in which the pal variant has a higher phenylalanine conversion activity and / or reduced immunogenicity, as compared to a pal wild type. the invention thus provides compositions of bacterial pal and biologically active fragments, mutants, variants and analogues thereof, as well as methods for the production, purification and use of such compositions for therapeutic and industrial purposes. |