| abstract |
pleuromutilin derivatives, pharmaceutical compositions comprising them and their uses. the present invention relates to a compound of the formula (i) wherein n is 0 to 4; m is 0 or 1 with the proviso that the sulfur atom and r3 are in the vicinal position (if m = 0 then r3 is in position 2, and if m = 1 then r3 is in position 1); r is ethyl or vinyl; r1 is hydrogen or (c1-8) alkyl, r2 is hydrogen or - (c3-6) cycloalkyl, or - (c1-6) unsubstituted alkyl, or - (c1-6) alkyl substituted by one or more of - hydroxy; preferably one or two, - methoxy, - halogen, - (c3-6) cycloalkyl or r1 and r2 together with the nitrogen atom to which they are attached form a 5- to 7-membered heterocyclic ring containing at least 1 nitrogen atom or 1 nitrogen and 1 additional heteroatom, for example, selected from n or o, or r1 is hydroxy and r2 is formyl; r3 is oh, or4, a halogen atom, or - with the proviso that r3 is linked to 2 r3 represents -o- (ch2) - with p is 2 or 3; r4 is (c1-6) alkyl or (c3-6) unsubstituted cycloalkyl. |