| abstract |
Substituted n-alkylated phenoxy thiazolidinediones, their use, pharmaceutical composition comprising them and process for preparing said pharmaceutical composition. The present invention relates to compounds of formula (I), methods for preparing these compounds, compositions, intermediates and derivatives thereof and for treating a condition including, but not limited to, ankylosing spondylitis, atherosclerosis, arthritis (such as rheumatoid arthritis, infectious arthritis, childhood arthritis, psoriatic arthritis, reactive arthritis), bone related diseases (including those related to bone formation), breast cancer (including those not responsive to anti-estrogen therapy), cardiovascular disorders, cartilage related disease (such as cartilage injury/loss, cartilage degeneration, and those referring to cartilage formation), chondrodysplasia, chondrosarcoma, chronic back injury, chronic bronchitis, chronic inflammatory airway disease, chronic obstructive pulmonary disease, diabetes, lung disorders. energy homeostasis, gout, pseudogout, lipid disorders, metabolic syndrome, multiple myeloma, obesity, osteoarthritis, osteogenesis imperfecta, osteolytic bone metastasis, osteomalacia, osteoporosis, paget's disease, periodontal disease, polymyalgia rheumatica, reiter syndrome, repetitive strain injury, hyperglycemia, elevated blood glucose level, and insulin resistance. |