http://rdf.ncbi.nlm.nih.gov/pubchem/patent/BR-PI0806812-A2
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_59e1d955a7b1560dc68cf7fd800e8fac http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_440b3059c9bcd1d85fd383f9b2ae1b40 |
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2317-76 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K2039-505 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K16-2866 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K39-395 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P43-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P37-06 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K45-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K39-395 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P37-06 |
| filingDate | 2008-01-23-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_b6e4797544bc820334fba2a513ff91cd http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_d927fec535a693d2b42607089ee559fd |
| publicationDate | 2011-09-13-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | BR-PI0806812-A2 |
| titleOfInvention | chronic rejection inhibitor |
| abstract | CHRONIC REJECTION INHIBITOR. The present invention relates to the effect of anti-IL-6 receptor antibodies suppressing chronic rejection reaction. The effect of anti-mouse IL-6 receptor antibody (MRI6-1) administration on suppression of the chronic rejection reaction was evaluated using a mouse rejection model for chronic rejection following heart transplantation. The result of histopathological analysis of extirpated transplanted hearts 60 days after transplantation revealed that fibrosis of vascular and myocardial stenotic lesions, which are characteristic pathological conditions of the chronic rejection reaction, were significantly suppressed in the MRI6- 1 when compared to the control group. Thus, administration of MRI 6-1 has been shown to have the effect of suppressing chronic rejection reaction. Specifically, the present invention first discovered that the chronic phase rejection reaction after organ transplantation was suppressed by administering an anti-IL-6 receptor antibody. |
| priorityDate | 2007-01-23-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 821.