| abstract |
SUMMARY OF (-) - (+) - 3- (Aminomethyl) -5-METHYL HEXANOIC ACID, (S) PREGABALINE. The invention encompasses the synthesis of (S) - (+) - 3- (aminomethyl) -5-methylhexanoic acid, (S) -pregabalin via an intermediate chiral of the following formula 4 wherein Ar is a C 6-6 aromatic group 10 -, R is a straight or branched C 1-4 alkyl, ester, or carboxylic acid, and R 1 is a straight or branched C 1- 1-5 substituted alkyl, aralkyl, or aralkyl. |