| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_2d6eb785a13032f52d1f7f654acac96d |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/Y02A50-30 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P33-02
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K36-062 |
| filingDate |
2008-04-09-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_85193eca23e6ec5a369fbd6bb881fa22
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_6c7c0c98860dcb437f30279e7519155b
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_0fc629a04a93cd35b52a3374b228f1d4
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_3784b173f0b031584ee10a84522e38fa
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_1b246847d69e63c3e6bc7fedbb1f773f
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_17324cbe89f20b27639265c35691ea25
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_c4815c0e588847164a1762570cebebad
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_5ddb0ff53680fa16fdc5c0a277695f97 |
| publicationDate |
2009-11-24-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
BR-PI0800947-A2 |
| titleOfInvention |
leishmanicidal metabolites and trypanothione reductase inhibitors isolated from the endophytic fungus cochliobolus sp. of piptadenia adiantoides |
| abstract |
Leishmanicidal and Inhibited Metabolites of the TRIPMIOTIONA REDUTASE ENZYME ISOLATED FROM ENDOPHYTIC FUNGUS COCHLIOBOLUS SP. OF ADYANTOID PIPTADENIA. The present invention relates to the use of two substances isolated and identified from the crude extract of the fungus Cochilobolus sp., Cochlioquinone A and isocochlioquinone A. The effect of both substances showed that cochlioquinone A inhibited the trypanothione reductase enzyme at a concentration of 20 <. 109> g / mL at 100%, while isocochlioquinone A showed no activity on this enzyme at the mentioned concentration. Both substances inhibited amastigoLas-like L. CL.) Amazonensis forms by 60 and 70%, respectively (at 20 <109> g mL). |
| priorityDate |
2008-04-09-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |