| abstract |
The present invention provides stable metastine derivatives having excellent biological activities (a cancer metastasis suppressing activity, a cancer growth suppressing activity, a secretion stimulating activity). gonadotropic hormone, sex hormone secretion stimulating activity, etc). By replacing the metastine-forming amino acids with specific amino acids, the metastine derivatives of the present invention achieve stability, solubility, and the like. improved blood levels, reduced tendency to gel formation, improved pharmacokinetics, as well as exhibiting excellent cancer metastasis suppressing activity or cancer growth suppressing activity. The metastine derivatives of the present invention also have an activity of suppressing gonadotropic hormone secretion, activity of suppressing sex hormone secretion, etc. |