http://rdf.ncbi.nlm.nih.gov/pubchem/patent/BR-PI0715459-A2
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_6a1fd88ba088f5e8b175cbd640f46551 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P29-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-0056 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-4468 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K9-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-4468 |
| filingDate | 2007-07-11-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_ce2e23f78ba466f5e61da1d4bc9294e5 |
| publicationDate | 2013-03-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | BR-PI0715459-A2 |
| titleOfInvention | Method for the production of fentanyl-based analgesics for their oral transmucosal administration in a candy-like dosage form |
| abstract | METHOD FOR THE PRODUCTION OF FENTANYL-BASED ANALGESTICS FOR THEIR ORAL TRANSMUCOSAL ADMINISTRATION IN A DOSED TYPE FORM The present invention relates to a method for producing fentanyl-based analgesics for their oral transmucosal administration in a candy-type dosage form, involving dissolving a pharmacologically acceptable amount of fentanyl citrate in purified water and dissolving it. of a pharmacologically acceptable dye in purified water. Polyalcohol sugar is mixed with purified water having a polyalcohol / sugar ratio of 17% to 19.5% by weight. Stir slowly under moderate heating until a homogeneous liquid mass is obtained. Sucrose is added to this liquid mass with a liquid mass / sucrose ratio between 65% and 67.5% by weight. The mass is heated and boiled at an initial temperature of 128 <198> C - 132 <198> C to a maximum temperature of 148 <198> C - 152 <198> C until the water content evaporate and the weight of the mass obtained in this step reaches between 88% and 90% by weight of the total initial weight of the net mass. The mass is allowed to cool to a temperature of about 128Â ° C, and the fentanyl citrate solutions of the coloring and flavoring agent are added, stirred firmly and maintained at the same temperature. This hot mixture is poured at a temperature of about 1300Â ° C into a mold or die. Before the candy mass solidifies, a handle may be incorporated into each piece of candy. When the mold is cold and the candy has solidified, it is removed from the mold and the pieces are immediately wrapped or bagged. |
| priorityDate | 2006-07-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 27.