| abstract |
PYRAZOLPYRIMIDINES, PROCESS FOR THE PREPARATION FOR THEREOF AS A MEDICINAL PRODUCT. The present invention relates to pyrazolpyrimidine derivatives of formula (I): wherein: Y1, R3, Y2, and Y3 are independently, for example, CR10, NH, S or O whereby at least one of Y ^ 1 ^, Y ^ 2 ^ and Y ^ 3 ^ denotes CR ^ 10 ^; R 13 represents chloro or bromo; R 2, R 4, R 4, R 5, R 6 and R 7 represent, for example, hydrogen or C 1 -C 6 alkyl, and R 2 ^ 10 ^ represents, for example, hydrogen, halogen or phenyl; which are potent modulators of mGluR5 and are, for example, useful for treating various neurological disorders. |