| abstract |
TRIAZOLIL FENIL BENZENOSULFONAMIDE COMPOSITION, COMPOSITION UNDERSTANDING, USES OF THE SAME, AND CCR2 AND CCR9 FUNCTION MODULATION METHODS. The present invention relates to compounds that act as potent CCR2 or CCR9 receptor antagonists. Animal experimentation demonstrates that these compounds are useful for treating inflammation, a disease characteristic of CCR2 and CCR9. The compounds are generally aryl sulfonamide derivatives and are useful in pharmaceutical compositions, methods for treating CCR2-mediated diseases, CCR9-mediated diseases, as controls in assays for identification of CCR2 antagonists and as controls in assays for the identification of CCR9 antagonists. |