abstract |
ARYL AND HETEROARYL-ETHYL ACYLGUANIDINE DERIVATIVES, THEIR PREPARATION, AND THEIR APPLICATION IN THERAPEUTICS. A compound of formula (I): wherein: a represents a febila, a heteroaryl or a (C4-C8) cycloalkyl group, Q represents an oxygen atom or a bond -CH2-, X, Y and Z represent carbon atoms or nitrogen, R1 and R2 are chosen from: hydrogen, jalogen, hydroxyl, cyano, oxo, -CF3, (C1-C6) alkyl, (C3-C8) cycloalkyl, -O- (C3-C8) cilcoalkyl, (CH2) m -SO2- (C1-C6) alkyl, benzyl, pyrazolyl, optionally substituted -CH2-triazolyl and -L-R12, wherein L represents a bond or a bond of -CH2-and / or-CO-and / or, - SO2-e R12 represents a (C3 -C8) cycloalkyl or a group of formula (a), (b), (c '), (d) or (e): R3 represents a linear (C1-C6) alkyl group which is optionally substituted, R4 represents a hydrogen or halogen atom or a hydroxyl, cyano, (C1-C6) alkyl or (C1-C6) alkoxy group, R5 and R6 independently of one another a hydrogen or halogen atom or a (C1-C5) alkyl group, or together form a (C3-C6) cycloalkyl group a, R7 and R8 represent a hydrogen atom or a (C1-C5) alkyl group, or together form a (C3-C6) cycloalkyl group, R9 and R10 represent a hydrogen atom or a hydroxyl group, CO- (C1- C6) alkyl or -C - (C1-C6) alkyl, or together form a straight (C2-C3) alkylene chain, R11 represents a hydrogen atom or an alkyl or cycloalkyl group, Processes for their preparation, their use in preparations therapeutic and pharmaceutical understand it. |