| abstract |
REPLACED FENY METANONE DERIVATIVES. The present invention relates to compounds of the general formula in which R1 is -OR1, heterocycloalkyl, aryl or heteroaryl, which are not substituted or substituted by lower alkyl or halogen; R1 is lower alkyl, lower alkyl substituted by halogen, or is - (CH2) 0- cycloalkyl; R2 is -S (O) 2 lower alkyl, -S (O) 2 NH lower alkyl, NO2 or CN; R3 is aryl or heteroaryl, which are not substituted or substituted by one to three substituents, selected from the group consisting of lower alkyl, lower alkoxy, CN. NO2 halogen, lower alkyl substituted by halogen, lower alkoxy substituted by halogen, aryl or sulfonamide; X is a bond, -CH2-, -NH -, - CH2O- or -OCH2-; n is 1 or 2; m is 1 or 2; o is 0 or 1; to the pharmaceutically acceptable acid addition salts thereof, to the pharmaceutical compositions containing it and its use in the treatment of neurological and neuropsychiatric disorders. It was found that the compounds of general formula I are good inhibitors of the glycine transporter 1 (GlyT-1) |