| abstract |
DIAGNOSTIC METHODS AND TREATMENT OF PREGNANCY COMPLICATIONS. The present invention relates to methods for the treatment of a pregnancy-related hypertensive disorder, such as pre-ecopia and eclampsia, using combinations of compounds that alter the levels of expression or biological activity of soluble endogline, endothelial nitric oxide synthase, PGI ~ 2 ~, TGF- <225> 1, TGF- <225> 3, activin A, BMP2, BMP7 and sFlt-1. Also disclosed are methods of diagnosing a pregnancy-related hypertensive disorder, such as pre-eclampsia or eclampsia, which include measuring any one or more of the following: levels of expression or biological activity of soluble endogline, endothelial nitric oxide synthase, PGI ~ 2 ~, TGF- <225> 1, TGF- <225> 3, activin A, BMP2, BMP7 and sFIt-1. |