| abstract |
PROCESS FOR THE PRODUCTION OF 2- [4- (3- AND 2- FLUORBENZYLXYL) BENZYLAMINE] PROPANAMIDS, ISOLATED SCHIFF BASE, SAFINAMIDE OR RALFINAMIDE, USE AND FORMULATIONS CONTAINING THE SAME. A process for obtaining 2- [4- (3- and 2- (fluorbenzyloxy) benzylamino] propanamides and their salts with high purity pharmaceutically acceptable acids, in particular with an impurity content of dibenzyl derivatives of less than 0.03%, preferably less than 0.01% by weight The process is carried out by subjecting Schiff 2- [4- (3- and 2- (fluoro-benzyloxy) benzylamino] propanamides) base intermediates to catalytic hydrogenation in the presence of a heterogeneous catalyst in a protic organic solvent. |