| abstract |
COMPOUND; PHARMACEUTICAL COMPOSITION; METHOD OF TREATMENT OR INHIBITION OF A PATHOLOGICAL CONDITION OR DISORDER MEDIATED BY A PROTEIN KINASE IN A MAMMER; AND USE OF THE COMPOUND The present teachings present a compound of formula I and its pharmaceutically acceptable salts, hydrates and esters, wherein R 4, R 2 and X are as defined herein. The present teachings also present methods of preparing the compounds of formula I and methods of treating autoimmune and inflammatory diseases by administering a therapeutically effective amount of a compound or compound of formula I to a mammal, including a human. |