| abstract |
2-ARYLPIRAZOL [1,5-alpha] PIRIMIDIN-3-IL ACETAMIDE DERIVATIVES AS BINDERS FOR TRANSLOCATING PROTEIN (18 kDa) The present invention relates to compounds of formula (l) radiolabeled with ^ 18 ^ F, ^ 123 ^ 1 ^ 76 ^ Br, ^ 124 ^ I or ^ 75 ^ Br and salts thereof, and a method of imaging transcriptional protein (l8kDa) (TSPO) in a patient comprising administering a compound of formula (l) radiolabeled with ^ 18 ^ F, ^ 123 ^ I ^ 76 ^ Br, ^ 124 ^ I or ^ 75 ^ Br or a pharmaceutically acceptable salt thereof. The invention provides fluoro-substituted compounds of formula (II) and salts thereof, and a method for treating a neurodegenerative disorder, inflammation or anxiety in a patient comprising administering a compound of formula (II) or a pharmaceutically acceptable salt thereof. |