| abstract |
PIRROLIDIN COMPOUNDS AS RENIN INHIBITORS. The present invention relates to pyrrolidine compounds 3,4-di-, 3,3,4-di-, 3,4,4, -tri- and 3,3,4,4-substituted tetra, these compounds for use in the diagnostic and therapeutic treatment of a homeothermic animal, especially for the treatment of a disease (= disorder) that depends on improper renin activity; the use of a compound of this class for the preparation of a pharmaceutical formulation for the treatment of a disease that depends on improper renin activity; the use of a compound of this class in the treatment of a disease that depends on improper renin activity; pharmaceutical formulations comprising said substituted pyrrolidine compound, and / or a treatment method comprising administering said substituted pyrrolidine compound, a method for making said substituted pyrrolidine compounds, and new intermediates and partial steps for their synthesis are described . Substituted pyrrolidine compounds are especially of formula I in which the substituents are as described in the specification. |