| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_2a819eda0adf22936a52362eeebb9fb4 |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K38-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/Y02A50-30
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/Y10T436-102499 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-33
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P13-12
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P17-02
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-435
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-43563
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-43581
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-47
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K38-02
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P7-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P7-04
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P7-06
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P7-08
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-04
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-10
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-12
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P43-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-43545
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-195 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12P21-04
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-42 |
| filingDate |
2007-05-21-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_dbd3b53179b5f6fc0c45e60d0b1a80f8
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_088b9fb005bbf116bab44af6ac8e1a5c
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_ea099e3c4bfa55a2f17bd3b4cd777de3
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_43d8f52f50d52c5c6858dc87986128c9 |
| publicationDate |
2012-01-10-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
BR-PI0711767-A2 |
| titleOfInvention |
compositions and methods for the release of nitric oxide |
| abstract |
COMPOSITIONS AND METHODS FOR NITRIC OXIDE RELEASE H-NOX proteins are mutated to exhibit enhanced kinetic and thermodynamic properties or ideal for blood release of NO gas. The engineered H-NOX proteins comprise mutations that transmit O ~ 2 ~ ligand binding or altered with respect to the corresponding wild-type H-NOX domain, and are operational as blood transporters of NO gas in physiologically compatible mammals. The invention also provides pharmaceutical compositions, kits and methods that use wild-type or mutant H-NOX proteins to treat any condition for which the release of NO is beneficial. |
| priorityDate |
2006-05-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |