http://rdf.ncbi.nlm.nih.gov/pubchem/patent/BR-PI0711659-A2
Outgoing Links
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|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_3dae6faca0f6a059c3befa58d4f8955c |
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| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P29-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-44 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D403-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D401-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D407-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D413-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D409-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D417-12 |
| filingDate | 2007-05-14-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_51bfae43a7817c57749591a5aaeb415e http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_0c19d3bb0a26a4c0ba7a0d2baea0b46f http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_62d82733cc204b0bc2b13b9fbf6d979e http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_fead298277baf23fd18efb1a50a2fd4d http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_4e079615132ebc224ba1675f0ab4a88e http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_45d5b10da8ceb73e8d7afdcf77d0523d http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_bda8e06a0c72e23a2cb4b47aeb91735b http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_afe76cf5d2e099c0c92786437d285bfe http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_1f4165f76dd75deff9c24a11bda8cc7d http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_65c980f1980c5cfb54a05edf425d6cb8 |
| publicationDate | 2012-01-17-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | BR-PI0711659-A2 |
| titleOfInvention | heterocyclic compounds for inhibition of integrins and their use |
| abstract | HETEROCYCLICAL COMPOUNDS FOR THE INHIBITION OF INTEGRINS AND THE USE OF THEM. The present invention relates to a compound of the formula (I) G-Z-A-Ar- <SYM>, where A is a radical selected from the group comprising 5-membered heterocyclic aromatic ring systems; Ar is a radical selected from the group comprising 5 and 6 membered aromatic ring systems optionally substituted, so the ring system contains 0.1, 2 or 3 heteroatoms selected from the group comprising N, O and S; Z is an individual radical and independently selected from the group comprising (CH ~ 2 ~) ~ n ~ -E- (CH ~ 2 ~) ~ m ~ -L- (CH ~ 2 ~) ~ k ~ e (CH ~ 2 ~) ~ m ~ -L- (CH ~ 2 ~) ~ k ~, where E is a radical which is absent or present, so if E is present, E is selected from the group comprising O, S, NH , NR ^ a ^, CO, SO, S0 ~ 2 ~, acetylene and substituted ethylene; L is a radical which is absent or present, so if L is present, L is individually and independently selected from the group comprising O, S , NH, NR ^ b ^, CO, SO, SO2 ~ 2 ~, substituted ethylene and acetylene; and k, m and n are individually and independently 0.1, 2 or 3; <sym> is a radical of formula (II), where Q is a radical selected from the group comprising a direct bond, C1-C4 alkyl, C = O, C = S, O, S, CR ^ a ^ R ^ b ^, NR ^ a ^ NR ^ b ^, N = N, CR ^ a ^ = N, N = CR ^ a ^, (C = 0) -O, O- (C = O), S0 ~ 2 ~ , NR ^ a ^, (C = O) -NR ^ a ^, NR ^ a ^ (C = O) -NR ^ b ^, NR ^ c ^ - (C = O), O- (C = O) -NR ^ c ^, NR ^ c ^ - (C = O) -O, NR ^ c ^ - (C = S), (C = S) -NR ^ c ^, NR ^ c ^ (C = S) -NR ^ d ^, NR ^ c ^ -SO ~ 2 ~ and SO ~ 2 ~ -NR ^ c ^. R ~ 1 ~, R ^ a ^, R ^ b ^, R ^ c ^ and R ^ d ^ are radicals which are individually and independently selected from the group comprising H, alkyl, substituted alkyl, cycloalkyl, substituted cycloalkyl, heterocyclyl substituted heterocyclyl, aryl, substituted aryl, heteroaryl, substituted heteroaryl, arylalkyl, substituted arylalkyl, heteroarilalquila substituted heteroarilalquila, cycloalkylalkyl, substituted cycloalkylalkyl, heterociclilalquila substituted heterociclilalquila, alkyloxy, alquiloxialquila substituted alquiloxialquila, alquiloxicicloalquila substituted alquiloxicicloalquila, alquiloxiheterociclila, alquiloxiheterociclila substituted , alkyloxyaryl, substituted alkyloxyaryl, alkyloxyethylaryl, substituted alkyloxyetheroaryl, alkylthioalkyl, substituted alkylthioalkyl, substituted alkylthiocycloalkyl and substituted alkylthiocycloalkyl, hydroxy, substituted hydroxy, oxo, thio, substituted thio, aminocarbonyl, aminocarbonyl oxide, formyl, substituted formyl, thioformyl, substituted thioformyl, amino, substituted amino, hydroxyl, substituted hydroxyl, mercapto, substituted mercapto, hydrazine, substituted hydrazine, diazene, substituted imine, substituted imine, amidino, substituted amidino, iminomethylamino, substituted iminomethylamino, ure oxide, substituted ureido, formylamino, substituted formylamino, substituted aminocarbonyloxy, substituted aminocarbonyloxy, hydroxycarbonylamino, substituted hydroxycarbonylamino, substituted hydroxycarbonyl, substituted hydroxycarbonyl, substituted formyloxy, substituted amylocarbonylamino, aminocarbonylamino, amine sufonil, substituted sulfonyl, sulfonamino, substituted sulfonamino, aminosulfonyl, substituted aminosulfonyl, cyan and halogen; R ~ 2 ~ is a hydrophobic moiety; R ~ 3 ~ is a radical selected from the group comprising OH, C1-C8 alkyloxy and aryl CO-C6 alkyloxy; R ~ 4 ~ is a radical selected from the group comprising hydrogen, halogen and C1-C4 alkyl; and G is a radical that contains a basic portion. |
| priorityDate | 2006-05-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
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