| abstract |
IAP BIR DOMAIN CONNECTION COMPOUNDS. The present invention discloses an isomer, enantiomer, diastereoisomer, tautomer, promedicament, pharmaceutically acceptable salt of a compound of formula I and pharmaceutical compositions thereof used to modulate the IAP function by means of preventing binding of a BIR binding protein with a BIR domain IAP and in the treatment of proliferative diseases such as cancer. also disclosed is a compound of formula 1 labeled with a detectable marker or affinity marker used as a probe in identifying a compound that binds to a BIR domain of the IAP. |