| abstract |
<B> ORGANIC COMPOUNDS. <D> The present invention relates to the discovery that certain compounds inhibit, regulate and / or modulate tyrosine and serine / threonine kinase and kinase-like proteins, such as RAF kinase, a serine / threonine kinase that functions in the MAP kinase signaling pathway, and involves compositions containing these compounds, and methods of using them to treat tyrosine and serine / threonine kinase-dependent diseases and kinase-like proteins, such as angiogenesis, cancer and cardiac hypertrophy. (Formula 1) |