http://rdf.ncbi.nlm.nih.gov/pubchem/patent/BR-PI0709742-A2
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_966a6c1f382ec9bcb5e3839dfd73e5b8 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D211-22 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-4465 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P43-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-451 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-22 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-24 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-451 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D211-22 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P25-24 |
| filingDate | 2007-03-26-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_9f811184bcd368b898cfc7aaf03ea193 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_dc9f9cbb162afca27e17d0e0de210e59 |
| publicationDate | 2011-07-26-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | BR-PI0709742-A2 |
| titleOfInvention | piperidine derivatives useful as serotonin transporter inhibitors and neurokinin-1 receptor antagonists |
| abstract | <B> PIPERIDINE DERIVATIVES EFFECTIVE AS SEROTONIN TRANSPORTER INHIBITORS AND NEUROKININ-1 RECEPTOR ANTAGONISTS <D> The present invention relates to trans- derivatives of Formula (1), where R ^ 1 ^ is hydrogen, halogen or lower alkyl; R ^ 2 ^ is hydrogen, lower alkyl or - (CH ~ 2 ~) ~ n ~ CN; R ^ 3 ^ is hydrogen or CF ~ 3 ~; n is 1 or 2; the dotted line may or may not be a link; and to pharmaceutically acceptable acid addition salts thereof. The compounds of Formulas (IA) and (IB) are encompassed by the present invention. The compounds of Formula (1) are good serotonin transporter inhibitors (SERT inhibitors) and, at the same time, they have good activity at the NK-1 receptor (double effect). Because of their effectiveness as SERT inhibitors, the compounds in the present invention are particularly useful for the treatment of CNS disorders and psychotic disorders, particularly in the treatment or prevention of depressive states and / or in the treatment of anxiety. |
| priorityDate | 2006-04-03-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 167.