| abstract |
2- (AMINOCYCLIC) -PIRlMtDONA DERIVATIVES A compound represented by the formula (1), an optically active isomer thereof, or a pharmaceutically acceptable salt thereof: wherein R ^ 2 ^ represents a hydrogen or similar; R3 represents a methyl or similar group; R ^ 20 ^ represents a simulated halogen atom; q represents an integer from 0 to 3; Z represents nitrogen atom, CH, the similar; R ^ 4 ^ represents .similar hydrogen; R ^ 5 ^ represents similar hydrogen; R6 represents substituted alkyloxy or the like; p represents an integer from 0 to 3; X represents bond, CH ~ 2 ~, oxygen atom, NH, or the like; any one or more of R ^ 5 ^ and R ^ 6 ^, R ^ 5 ^ and R ^ 4 ^, R ^ 6 ^ and R ^ 4 ^, X and R ^ 5 ^, X and R ^ 4 ^, X and R ^ 6 ^, and R ^ 6 ^ and R ^ 6 ^ can combine together to form a ring, which is used for preventive and / or therapeutic treatment of a disease caused by hyperactivity of the tau kinase 1 protein such as diseases neurodegenerative (eg Alzheimer's disease). |