| abstract |
NITROGENED HETEROCYCLIC DERIVATIVE, AND PHARMACEUTICAL AGENT UNDERSTANDING THE DERIVATIVE AS AN ACTIVE INGREDIENT. The compound represented by the formula (Y), a salt of it, an N-oxide of it, a solvate of it, or a prodrug of it specifically binds to CCR5, being useful to prevent and / or treat diseases related to CCR5, for example, several inflammatory diseases (asthma, nephritis, nephropathy, hepatitis, arthritis, rheumatoid arthritis, rhinitis, conjunctivitis, ulcerative colitis, etc.), immunological diseases (autoimmune diseases, organ transplant rejection, immunosuppression, psoriasis, sclerosis multiple, etc.), infectious diseases (infection with human immunodeficiency virus, acquired immunodeficiency syndrome, etc.), allergic diseases (atopic dermatitis, urticaria, allergic bronchopulmonary aspergillosis, allergic eosinophilic gastroenteritis, etc.), ischemic reperfusion injury, acute respiratory distress syndrome, shock associated with bacterial infection, diabetes, cancer metastasis and so on. Where all symbols in the formula are as defined in the specification. |