| abstract |
THERAPEUTIC PIPIRAZINS AS PDE4 INHIBITORS The invention includes a compound of formula 1; where R ~ 1 ~, X, Z, n, and m have any of the values described herein, as well as salts of such a compound, compositions comprising such compounds, and therapeutic methods comprising administering such a compound. The compounds are inhibitors of PDE4 function and are useful for improving cognitive function in animals. |