| abstract |
coumarin derivative having antitumor activity the present invention provides a compound represented by the general formula (1) below or a pharmaceutically acceptable salt thereof: where: x is selected from heteroaryl etc., y ^ 1 ^ y and ^ 2 ^ are selected from - n = etc., y ^ 3 ^ and y ^ 4 ^ are selected from -ch = etc., a is selected from sulfamide etc., r ^ 1 ^ is selected from hydrogen etc., and r ^ 2 ^ is selected from c ~ 1 -6 aiquita etc. the compound or salt has sufficiently high antitumor activity, and is useful in the treatment of cell proliferative disorders, particularly cancers. the present invention also provides a pharmaceutical composition containing the compound or salt as an active ingredient. |